Publication:
Timing of CD8(+) T Cell Responses in Relation to Commencement of Capillary Leakage in Children with Dengue

dc.contributor.authorSimmons, Cameron
dc.date.accessioned2018-09-14T11:14:56Z
dc.date.available2017-07-12T05:11:31Z
dc.date.available2018-09-14T11:14:56Z
dc.date.issued2010-06-15en_US
dc.description.abstractImmune activation is a feature of dengue hemorrhagic fever (DHF) and CD8+ T cell responses in particular have been suggested as having a role in the vasculopathy that characterizes this disease. By phenotyping CD8+ T cells (CD38+/HLA-DR+, CD38+/Ki-67+, or HLA-DR+/Ki-67+) in serial blood samples from children with dengue, we found no evidence of increased CD8+ T cell activation prior to the commencement of resolution of viremia or hemoconcentration. Investigations with MHC class I tetramers to detect NS3(133-142)-specific CD8+ T cells in two independent cohorts of children suggested the commencement of hemoconcentration and thrombocytopenia in DHF patients generally begins before the appearance of measurable frequencies of NS3(133-142)-specific CD8+ T cells. The temporal mismatch between the appearance of measurable surface activated or NS3(133-142)-specific CD8+ T cells suggests that these cells are sequestered at sites of infection, have phenotypes not detected by our approach, or that other mechanisms independent of CD8+ T cells are responsible for early triggering of capillary leakage in children with DHF.
dc.identifier.urihttps://demo7.dspace.org/handle/10673/121
dc.languageEnglishen_US
dc.titleTiming of CD8(+) T Cell Responses in Relation to Commencement of Capillary Leakage in Children with Dengueen_US
dc.typeJournal Article
dspace.entity.typePublication
relation.isAuthorOfPublicationb1b2c768-bda1-448a-a073-fc541e8b24d9
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