Publication:
Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma

dc.contributor.authorSimmons, Cameron
dc.date.accessioned2018-09-14T11:15:10Z
dc.date.available2017-07-12T03:58:34Z
dc.date.available2012-08-01en_US
dc.date.available2012-08-01en_US
dc.date.available2012-08-01en_US
dc.date.available2012-08-01en_US
dc.date.available2012-08-01en_US
dc.date.available2012-08-01en_US
dc.date.available2012-08-01en_US
dc.date.available2012-08-01en_US
dc.date.available2012-08-01en_US
dc.date.available2012-08-01en_US
dc.date.available2018-09-14T11:15:10Z
dc.date.issued2012-10-01en_US
dc.description.abstractPrimary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR)=1.22; P=5.33×10(-12)), rs3753841 in COL11A1 (per-allele OR=1.20; P=9.22×10(-10)) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR=1.50; P=3.29×10(-9)). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG.
dc.identifier.urihttps://demo7.dspace.org/handle/10673/224
dc.languageEnglishen_US
dc.titleGenome-wide association analyses identify three new susceptibility loci for primary angle closure glaucomaen_US
dc.typeJournal Article
dspace.entity.typePublication
relation.isAuthorOfPublicationb1b2c768-bda1-448a-a073-fc541e8b24d9
relation.isAuthorOfPublication.latestForDiscoveryb1b2c768-bda1-448a-a073-fc541e8b24d9
Files
Collections