Publication:
ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma

dc.date.accessioned 2018-09-14T11:15:11Z
dc.date.available 2015-11-24T00:49:41Z
dc.date.available 2013-11-19 en_US
dc.date.available 2013-11-19 en_US
dc.date.available 2013-11-19 en_US
dc.date.available 2013-11-19 en_US
dc.date.available 2013-11-19 en_US
dc.date.available 2013-11-19 en_US
dc.date.available 2013-11-19 en_US
dc.date.available 2013-11-19 en_US
dc.date.available 2013-11-19 en_US
dc.date.available 2013-11-19 en_US
dc.date.available 2018-09-14T11:15:11Z
dc.date.issued 2014-03-01 en_US
dc.description.abstract Anterior chamber depth (ACD) is a key anatomical risk factor for primary angle closure glaucoma (PACG). We conducted a genome-wide association study (GWAS) on ACD to discover novel genes for PACG on a total of 5,308 population-based individuals of Asian descent. Genome-wide significant association was observed at a sequence variant within ABCC5 (rs1401999; per-allele effect size =  -0.045 mm, P = 8.17 × 10(-9)). This locus was associated with an increase in risk of PACG in a separate case-control study of 4,276 PACG cases and 18,801 controls (per-allele OR = 1.13 [95% CI: 1.06-1.22], P = 0.00046). The association was strengthened when a sub-group of controls with open angles were included in the analysis (per-allele OR = 1.30, P = 7.45 × 10(-9); 3,458 cases vs. 3,831 controls). Our findings suggest that the increase in PACG risk could in part be mediated by genetic sequence variants influencing anterior chamber dimensions.
dc.identifier.uri https://demo7.dspace.org/handle/10673/229
dc.language English en_US
dc.title ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma en_US
dc.type Journal Article
dspace.entity.type Publication
relation.isAuthorOfPublication b1b2c768-bda1-448a-a073-fc541e8b24d9
Files
Collections