Publication:
Complex dynamic of dengue virus serotypes 2 and 3 in Cambodia following series of climate disasters

dc.date.accessioned 2018-09-14T11:15:04Z
dc.date.available 2017-07-12T03:49:52Z
dc.date.available 2012-05-16 en_US
dc.date.available 2012-05-16 en_US
dc.date.available 2012-05-16 en_US
dc.date.available 2012-05-16 en_US
dc.date.available 2012-05-16 en_US
dc.date.available 2012-05-16 en_US
dc.date.available 2012-05-16 en_US
dc.date.available 2012-05-16 en_US
dc.date.available 2018-09-14T11:15:04Z
dc.date.issued 2013-04-01 en_US
dc.description.abstract The Dengue National Control Program was established in Cambodia in 2000 and has reported between 10,000 and 40,000 dengue cases per year with a case fatality rate ranging from 0.7 to 1.7. In this study 39 DENV-2 and 57 DENV-3 viruses isolated from patients between 2000 and 2008 were fully sequenced. Five DENV2 and four DENV3 distinct lineages with different dynamics were identified. Each lineage was characterized by the presence of specific mutations with no evidence of recombination. In both DENV-2 and DENV-3 the lineages present prior to 2003 were replaced after that date by unrelated lineages. After 2003, DENV-2 lineages D2-3 and D2-4 cocirculated until 2007 when they were almost completely replaced by a lineage D2-5 which emerged from D2-3 Conversely, all DENV-3 lineages remained, diversified and cocirculated with novel lineages emerging. Years 2006 and 2007 were marked by a high prevalence of DENV-3 and 2007 with a large dengue outbreak and a high proportion of patients with severe disease. Selective sweeps in DENV-1 and DENV-2 were linked to immunological escape to a predominately DENV-3-driven immunological response. The complex dynamic of dengue in Cambodia in the last ten years has been associated with a combination of stochastic climatic events, cocirculation, coevolution, adaptation to different vector populations, and with the human population immunological landscape.
dc.identifier.uri https://demo7.dspace.org/handle/10673/181
dc.language English en_US
dc.title Complex dynamic of dengue virus serotypes 2 and 3 in Cambodia following series of climate disasters en_US
dc.type Journal Article
dspace.entity.type Publication
relation.isAuthorOfPublication b1b2c768-bda1-448a-a073-fc541e8b24d9
Files
Collections