Publication:
Dengue viruses cluster antigenically but not as discrete serotypes

dc.contributor.authorSimmons, Cameron
dc.date.accessioned2018-09-14T11:14:55Z
dc.date.available2017-05-24T05:15:49Z
dc.date.available2018-09-14T11:14:55Z
dc.date.issued2015-09-18en_US
dc.description.abstractThe four genetically divergent dengue virus (DENV) types are traditionally classified as serotypes. Antigenic and genetic differences among the DENV types influence disease outcome, vaccine-induced protection, epidemic magnitude, and viral evolution. We characterized antigenic diversity in the DENV types by antigenic maps constructed from neutralizing antibody titers obtained from African green monkeys and after human vaccination and natural infections. Genetically, geographically, and temporally, diverse DENV isolates clustered loosely by type, but we found that many are as similar antigenically to a virus of a different type as to some viruses of the same type. Primary infection antisera did not neutralize all viruses of the same DENV type any better than other types did up to 2 years after infection and did not show improved neutralization to homologous type isolates. That the canonical DENV types are not antigenically homogeneous has implications for vaccination and research on the dynamics of immunity, disease, and the evolution of DENV.
dc.identifier.urihttps://demo7.dspace.org/handle/10673/116
dc.languageEnglishen_US
dc.titleDengue viruses cluster antigenically but not as discrete serotypesen_US
dc.typeJournal Article
dspace.entity.typePublication
relation.isAuthorOfPublicationb1b2c768-bda1-448a-a073-fc541e8b24d9
relation.isAuthorOfPublication.latestForDiscoveryb1b2c768-bda1-448a-a073-fc541e8b24d9
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