Publication:
Pathophysiology and prognosis in Vietnamese adults with tuberculous meningitis

dc.contributor.author Simmons, Cameron
dc.date.accessioned 2018-09-14T11:15:03Z
dc.date.available 2017-07-05T05:25:27Z
dc.date.available 2003-04-30 en_US
dc.date.available 2003-04-30 en_US
dc.date.available 2003-04-30 en_US
dc.date.available 2003-04-30 en_US
dc.date.available 2003-04-30 en_US
dc.date.available 2003-04-30 en_US
dc.date.available 2003-04-30 en_US
dc.date.available 2003-04-30 en_US
dc.date.available 2018-09-14T11:15:03Z
dc.date.issued 2003-10-15 en_US
dc.description.abstract The pathogenesis of tuberculous meningitis remains unclear, and there are few data describing the kinetics of the immune response during the course of its treatment. We measured concentrations of pro- and anti-inflammatory cytokines in serial blood and cerebrospinal fluid (CSF) samples from 21 adults who were being treated for tuberculous meningitis. CSF concentrations of soluble tumor necrosis factor-alpha receptors and of matrix metalloprotein-9 and its tissue inhibitor were also measured, and blood-brain barrier permeability was assessed by the albumin and IgG partition indices. CSF concentrations of lactate, interleukin-8, and interferon-gamma were high before treatment and then decreased rapidly with antituberculosis chemotherapy. However, significant immune activation and blood-brain barrier dysfunction were still apparent after 60 days of treatment. Death was associated with high initial CSF concentrations of lactate, low numbers of white blood cells, in particular neutrophils, and low CSF glucose levels.
dc.identifier.uri https://demo7.dspace.org/handle/10673/175
dc.language English en_US
dc.title Pathophysiology and prognosis in Vietnamese adults with tuberculous meningitis en_US
dc.type Journal Article
dspace.entity.type Publication
relation.isAuthorOfPublication b1b2c768-bda1-448a-a073-fc541e8b24d9
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