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- PublicationTiming of CD8(+) T Cell Responses in Relation to Commencement of Capillary Leakage in Children with Dengue(2010-06-15)Immune activation is a feature of dengue hemorrhagic fever (DHF) and CD8+ T cell responses in particular have been suggested as having a role in the vasculopathy that characterizes this disease. By phenotyping CD8+ T cells (CD38+/HLA-DR+, CD38+/Ki-67+, or HLA-DR+/Ki-67+) in serial blood samples from children with dengue, we found no evidence of increased CD8+ T cell activation prior to the commencement of resolution of viremia or hemoconcentration. Investigations with MHC class I tetramers to detect NS3(133-142)-specific CD8+ T cells in two independent cohorts of children suggested the commencement of hemoconcentration and thrombocytopenia in DHF patients generally begins before the appearance of measurable frequencies of NS3(133-142)-specific CD8+ T cells. The temporal mismatch between the appearance of measurable surface activated or NS3(133-142)-specific CD8+ T cells suggests that these cells are sequestered at sites of infection, have phenotypes not detected by our approach, or that other mechanisms independent of CD8+ T cells are responsible for early triggering of capillary leakage in children with DHF.
- PublicationThe International Postal Network and Other Global Flows as Proxies for National Wellbeing(Public Library of Science, 01/06/16)
- PublicationThe ionized gas in nearby galaxies as traced by the [N II] 122 and 205 μm transitions(Institute of Physics, 2016)
- PublicationThe Vanishing Atrial Mass(Oxford University Press, 07/07/16)