The rate of decline of CD4 T-cells in people infected with HIV

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Authors
Williams, Brian G.
Korenromp, Eline L.
Gouws, Eleanor
Dye, Christopher
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Abstract
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In people infected with HIV the RNA viral load is a good predictor of the rate of loss of CD4 cells at a population level but there is still great variability in the rate of decline of CD4 cells among individuals. Here we show that the pre-infection distribution of CD4 cell counts and the distribution of survival times together account for 87% of the variability in the observed rate of decline of CD4 cells among individuals. The challenge is to understand the variation in CD4 levels, among populations and individuals, and to establish the determinants of survival of which viral load may be the most important.
Comment: Two pages with one figure
Keywords
Quantitative Biology - Cell Behavior, Quantitative Biology - Quantitative Methods
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