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The epidemiology and aetiology of diarrhoeal disease in infancy in southern Vietnam: a birth cohort study

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dc.contributor.author Simmons, Cameron
dc.date.accessioned 2018-09-14T11:14:58Z
dc.date.available 2017-07-12T03:21:50Z
dc.date.available 2015-03-17 en_US
dc.date.available 2015-03-17 en_US
dc.date.available 2015-03-17 en_US
dc.date.available 2015-03-17 en_US
dc.date.available 2015-03-17 en_US
dc.date.available 2015-03-17 en_US
dc.date.available 2015-03-17 en_US
dc.date.available 2015-03-17 en_US
dc.date.available 2018-09-14T11:14:58Z
dc.date.issued 2015-06-01 en_US
dc.description.abstract OBJECTIVES: Previous studies indicate a high burden of diarrhoeal disease in Vietnamese children, however longitudinal community-based data on burden and aetiology are limited. The findings from a large, prospective cohort study of diarrhoeal disease in infants in southern Vietnam are presented herein. METHODS: Infants were enrolled at birth in urban Ho Chi Minh City and a semi-rural district in southern Vietnam, and followed for 12 months (n=6706). Diarrhoeal illness episodes were identified through clinic-based passive surveillance, hospital admissions, and self-reports. RESULTS: The minimum incidence of diarrhoeal illness in the first year of life was 271/1000 infant-years of observation for the whole cohort. Rotavirus was the most commonly detected pathogen (50% of positive samples), followed by norovirus (24%), Campylobacter (20%), Salmonella (18%), and Shigella (16%). Repeat infections were identified in 9% of infants infected with rotavirus, norovirus, Shigella, or Campylobacter, and 13% of those with Salmonella infections. CONCLUSIONS: The minimum incidence of diarrhoeal disease in infants in both urban and semi-rural settings in southern Vietnam was quantified prospectively. A large proportion of laboratory-diagnosed disease was caused by rotavirus and norovirus. These data highlight the unmet need for a rotavirus vaccine in Vietnam and provide evidence of the previously unrecognized burden of norovirus in infants.
dc.identifier.uri https://demo7.dspace.org/handle/123456789/138
dc.language English en_US
dc.title The epidemiology and aetiology of diarrhoeal disease in infancy in southern Vietnam: a birth cohort study en_US
dc.type Journal Article
dspace.entity.type Publication
relation.isAuthorOfPublication b1b2c768-bda1-448a-a073-fc541e8b24d9
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