Recent Developments in Immune Network Theory including a concept for an HIV Vaccine

Hoffmann, Geoffrey W.
Journal Title
Journal ISSN
Volume Title
The symmetrical network theory is a framework for understanding the immune system, that dates back to the mid 1970s. The symmetrical network theory is based on symmetrical stimulatory, inhibitory and killing interactions between clones that are specific for each other. Previous papers described roles for helper and suppressor T cells in regulating immune responses and a model for HIV pathogenesis. This paper extends the theory to account for regulatory T cells that include three types of suppressor cells called Ts1, Ts2 and Ts3, and two types of helper cells called Th1 and Th2. The theory leads to a concept for an HIV vaccine, namely a reagent commonly known as IVIG, to be administered in small amounts in an immunogenic form via an immunogenic route. Predictions are made for experiments in mice and macaque monkeys.
Comment: Predictions of the theory for experiments in mice and macaque monkeys have been added
Quantitative Biology - Populations and Evolution, Quantitative Biology - Molecular Networks