Publication:
Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals

dc.contributor.author Simmons, Cameron
dc.date.accessioned 2018-09-14T11:14:49Z
dc.date.available 2017-07-12T02:11:10Z
dc.date.available 2008-07-30 en_US
dc.date.available 2008-07-30 en_US
dc.date.available 2008-07-30 en_US
dc.date.available 2008-07-30 en_US
dc.date.available 2008-07-30 en_US
dc.date.available 2008-07-30 en_US
dc.date.available 2008-07-30 en_US
dc.date.available 2008-07-30 en_US
dc.date.available 2018-09-14T11:14:49Z
dc.date.issued 2008-10-01 en_US
dc.description.abstract The threat of avian influenza A (H5N1) infection in humans remains a global health concern. Current influenza vaccines stimulate antibody responses against the surface glycoproteins but are ineffective against strains that have undergone significant antigenic variation. An alternative approach is to stimulate pre-existing memory T cells established by seasonal human influenza A infection that could cross-react with H5N1 by targeting highly conserved internal proteins. To determine how common cross-reactive T cells are, we performed a comprehensive ex vivo analysis of cross-reactive CD4+ and CD8+ memory T cell responses to overlapping peptides spanning the full proteome of influenza A/Viet Nam/CL26/2005 (H5N1) and influenza A/New York/232/2004 (H3N2) in healthy individuals from the United Kingdom and Viet Nam. Memory CD4+ and CD8+ T cells isolated from the majority of participants exhibited human influenza-specific responses and showed cross-recognition of at least one H5N1 internal protein. Participant CD4+ and CD8+ T cells recognized multiple synthesized influenza peptides, including peptides from the H5N1 strain. Matrix protein 1 (M1) and nucleoprotein (NP) were the immunodominant targets of cross-recognition. In addition, cross-reactive CD4+ and CD8+ T cells recognized target cells infected with recombinant vaccinia viruses expressing either H5N1 M1 or NP. Thus, vaccine formulas inducing heterosubtypic T cell-mediated immunity may confer broad protection against avian and human influenza A viruses.
dc.identifier.uri https://demo7.dspace.org/handle/123456789/60
dc.language English en_US
dc.title Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals en_US
dc.type Journal Article
dspace.entity.type Publication
relation.isAuthorOfPublication b1b2c768-bda1-448a-a073-fc541e8b24d9
relation.isJournalIssueOfPublication 4a45cacd-9653-437b-92cf-5824b0461f84
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