Publication:
Corticosteroids for Dengue - Why Don't They Work?
Corticosteroids for Dengue - Why Don't They Work?
| dc.contributor.author | Simmons, Cameron | |
| dc.date.accessioned | 2018-09-14T11:15:06Z | |
| dc.date.available | 2017-07-12T03:36:54Z | |
| dc.date.available | 2013-10-31 | en_US |
| dc.date.available | 2013-10-31 | en_US |
| dc.date.available | 2013-10-31 | en_US |
| dc.date.available | 2013-10-31 | en_US |
| dc.date.available | 2013-10-31 | en_US |
| dc.date.available | 2013-10-31 | en_US |
| dc.date.available | 2013-10-31 | en_US |
| dc.date.available | 2013-10-31 | en_US |
| dc.date.available | 2018-09-14T11:15:06Z | |
| dc.date.issued | 2013-12-01 | en_US |
| dc.description.abstract | BACKGROUND: Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue. FINDINGS: In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. Prominent among the 81 transcripts were those associated with T and NK cell cytolytic functions. Additionally, prednisolone therapy was not associated with changes in plasma cytokine levels. CONCLUSION: The inability of prednisolone treatment to markedly attenuate the host immune response is instructive for planning future therapeutic strategies for dengue. | |
| dc.identifier.uri | https://demo7.dspace.org/handle/123456789/197 | |
| dc.language | English | en_US |
| dc.title | Corticosteroids for Dengue - Why Don't They Work? | en_US |
| dc.type | Journal Article | |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | b1b2c768-bda1-448a-a073-fc541e8b24d9 |