Publication:
Variation at HLA-DRB1 is associated with resistance to enteric fever

dc.contributor.author Simmons, Cameron
dc.date.accessioned 2018-09-14T11:15:04Z
dc.date.available 2017-07-12T03:29:04Z
dc.date.available 2014-10-15 en_US
dc.date.available 2014-10-15 en_US
dc.date.available 2014-10-15 en_US
dc.date.available 2014-10-15 en_US
dc.date.available 2014-10-15 en_US
dc.date.available 2014-10-15 en_US
dc.date.available 2014-10-15 en_US
dc.date.available 2014-10-15 en_US
dc.date.available 2018-09-14T11:15:04Z
dc.date.issued 2014-12-01 en_US
dc.description.abstract Enteric fever affects more than 25 million people annually and results from systemic infection with Salmonella enterica serovar Typhi or Paratyphi pathovars A, B or C(1). We conducted a genome-wide association study of 432 individuals with blood culture-confirmed enteric fever and 2,011 controls from Vietnam. We observed strong association at rs7765379 (odds ratio (OR) for the minor allele = 0.18, P = 4.5 × 10(-10)), a marker mapping to the HLA class II region, in proximity to HLA-DQB1 and HLA-DRB1. We replicated this association in 595 enteric fever cases and 386 controls from Nepal and also in a second independent collection of 151 cases and 668 controls from Vietnam. Imputation-based fine-mapping across the extended MHC region showed that the classical HLA-DRB1*04:05 allele (OR = 0.14, P = 2.60 × 10(-11)) could entirely explain the association at rs7765379, thus implicating HLA-DRB1 as a major contributor to resistance against enteric fever, presumably through antigen presentation.
dc.identifier.uri https://demo7.dspace.org/handle/123456789/184
dc.language English en_US
dc.title Variation at HLA-DRB1 is associated with resistance to enteric fever en_US
dc.type Journal Article
dspace.entity.type Publication
relation.isAuthorOfPublication b1b2c768-bda1-448a-a073-fc541e8b24d9
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