Hybrid Elastic/Discrete-Particle Approach to Biomembrane Dynamics with Application to the Mobility of Curved Integral Membrane Proteins

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Authors
Naji, Ali
Atzberger, Paul J.
Brown, Frank L. H.
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Abstract
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We introduce a simulation strategy to consistently couple continuum biomembrane dynamics to the motion of discrete biological macromolecules residing within or on the membrane. The methodology is used to study the diffusion of integral membrane proteins that impart a curvature on the bilayer surrounding them. Such proteins exhibit a substantial reduction in diffusion coefficient relative to "flat" proteins; this effect is explained by elementary hydrodynamic considerations.
Comment: 4 pages, 2 figures
Keywords
Condensed Matter - Soft Condensed Matter, Condensed Matter - Statistical Mechanics
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