Publication:
Genetic epidemiology of dengue viruses in phae III trials of the CYD tetravalent dengue vaccine and implications for efficacy

dc.contributor.author Simmons, Cameron
dc.date.accessioned 2018-09-14T11:15:03Z
dc.date.available 2017-10-11T01:12:07Z
dc.date.available 2017-08-03 en_US
dc.date.available 2017-08-03 en_US
dc.date.available 2017-08-03 en_US
dc.date.available 2017-08-03 en_US
dc.date.available 2017-08-03 en_US
dc.date.available 2017-08-03 en_US
dc.date.available 2017-08-03 en_US
dc.date.available 2017-08-03 en_US
dc.date.available 2017-08-03 en_US
dc.date.available 2017-08-03 en_US
dc.date.available 2017-08-03 en_US
dc.date.available 2017-08-03 en_US
dc.date.available 2018-09-14T11:15:03Z
dc.date.issued 2017-09-05 en_US
dc.description.abstract This study defined the genetic epidemiology of dengue viruses (DENV) in two pivotal phase III trials of the tetravalent dengue vaccine, CYD-TDV, and thereby enabled virus genotype-specific estimates of vaccine efficacy (VE). Envelope gene sequences (n = 661) from 11 DENV genotypes in 10 endemic countries provided a contemporaneous global snapshot of DENV population genetics and revealed high amino acid identity between the E genes of vaccine strains and wild-type viruses from trial participants, including at epitope sites targeted by virus neutralising human monoclonal antibodies. Post-hoc analysis of all CYD14/15 trial participants revealed a statistically significant genotype-level VE association within DENV-4, where efficacy was lowest against genotype I. In subgroup analysis of trial participants age 9-16 years, VE estimates appeared more balanced within each serotype, suggesting that genotype-level heterogeneity may be limited in older children. Post-licensure surveillance is needed to monitor vaccine performance against the backdrop of DENV sequence diversity and evolution.
dc.identifier.uri https://demo7.dspace.org/handle/123456789/180
dc.language English en_US
dc.title Genetic epidemiology of dengue viruses in phae III trials of the CYD tetravalent dengue vaccine and implications for efficacy en_US
dc.type Journal Article
dspace.entity.type Publication
relation.isAuthorOfPublication b1b2c768-bda1-448a-a073-fc541e8b24d9
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