Publication:
Evolutionarily Successful Asian 1 Dengue Virus 2 Lineages Contain One Substitution in Envelope That Increases Sensitivity to Polyclonal Antibody Neutralization

dc.contributor.author Simmons, Cameron
dc.date.accessioned 2018-09-14T11:14:56Z
dc.date.available 2017-02-28T23:15:12Z
dc.date.available 2015-11-04 en_US
dc.date.available 2015-11-04 en_US
dc.date.available 2015-11-04 en_US
dc.date.available 2015-11-04 en_US
dc.date.available 2015-11-04 en_US
dc.date.available 2015-11-04 en_US
dc.date.available 2015-11-04 en_US
dc.date.available 2015-11-04 en_US
dc.date.available 2018-09-14T11:14:56Z
dc.date.issued 2016-03-15 en_US
dc.description.abstract The 4 dengue virus serotypes (DENV-1-4) cause the most prevalent mosquito-borne viral disease of humans worldwide. DENV-2 Asian 1 (A1) genotype viruses replaced the Asian-American (AA) genotype in Vietnam and Cambodia, after which A1 viruses containing Q or M at envelope (E) residue 160 became more prevalent than those with residue 160K in both countries (2008-2011). We investigated whether these substitutions conferred a fitness advantage by measuring neutralizing antibody titer against reporter virus particles (RVPs) representing AA, A1-160K, A1-160Q, and A1-160M, using patient sera from Vietnam and a well-characterized Nicaraguan cohort. Surprisingly, we found that A1-160Q and A1-160M RVPs were better neutralized by heterologous antisera than A1-160K. Despite this, Vietnamese patients infected with A1-160Q or A1-160M viruses had higher viremia levels than those infected with A1-160K. We thus found that independent lineages in Vietnam and Cambodia acquired a substitution in E that significantly increased polyclonal neutralization but nonetheless were successful in disseminating and infecting human hosts.
dc.identifier.uri https://demo7.dspace.org/handle/123456789/117
dc.language English en_US
dc.title Evolutionarily Successful Asian 1 Dengue Virus 2 Lineages Contain One Substitution in Envelope That Increases Sensitivity to Polyclonal Antibody Neutralization en_US
dc.type Journal Article
dspace.entity.type Publication
relation.isAuthorOfPublication b1b2c768-bda1-448a-a073-fc541e8b24d9
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